Drug targets.
Evolved.
Solved.

Evolution has solved disease many times, in many species. Primordial's AI learns from 100 million years of evolutionary data across hundreds of species to uncover, translate, and rank the most valuable drug targets for next-generation drug development or investment.

Primordial AI drug target discovery for pharma.

Hard science. Functionally validated.

Our drug target discovery A.I. platform has 5 years of functional-validation in wet labs and knockout mice: metabolism, obesity, brain aging, behavior.

Phenotypic Ranking

Matches gene targets to phenotypic effects revealed from human data, evolutionary data, and proprietary genetic recipes.

Biologic Ranking

Finds the most biologically influential drug targets.

Primordial Genetic Recipes

Proprietary gene mechanisms and pathways for optimal therapy intervention.

Diabetes

Naturally selected.

Backed by a 100 million years of real-world trials. The most important and influential drug targets for multiple major diseases - revealed, ranked, and ready to go.
‍

Let's go

Neurodegeneration

Obesity

Cancer

Alzheimer's

Inflammation & Immunity

We take the long view of success.

Mother Nature has spent 100 million years perfecting solutions to disease. From the resistance to cancer found in elephants, whales, and sharks, to the remarkable longevity of the immortal jellyfish and ocean quahog, nature holds the key to health.

Hibernators like the brown bear, fat-tailed lemur, and 13-lined ground squirrel possess extraordinary metabolic superpowers. They exhibit increased longevity, resistance to muscle atrophy, neuroprotection, and reversible insulin resistance. Lineages that evolved hibernation reveal the most valuable drug targets for Obesity, Diabetes, Alzheimer's, Cancer, Cachexia, and more.

As leaders in evolutionary genomics we were aware long ago that natural selection had evolved solutions for the same diseases many times in unrelated species, and that these solutions were key to human disease.

For the last 15 years or scientists have delved into the genomic data of species evolution and human disease to uncover and understand novel gene pathways from hundreds of multi-omics datasets. We analyzed genomes and annotated biomedical phenotypes for hundreds of species, identifying gene-trait associations.

Our functionally validated algorithms for drug target discovery and ranking present the first comprehensive genetic map for mammalian and human metabolic control.

We've already discovered and ranked primary targets for major chronic human diseases, with proprietary metabolic, genetic and cellular recipes for disease recovery. We call them Primordial Pathways.

So, before you end up betting on the wrong target, discover how Primordial can give you the right one.

Show me the @top 25 @gene targets to @inhibit @obesity and only include targets that are ranked as @highly druggable and are @novel.

Find the @top 3 @novel @GPCR targets that @inhibit @Alzheimer's and list by @fewest @predicted @side effects.

Metabolic & Genetic Mechanisms

Most protein-coding genes are conserved across mammals and new traits often evolve through changes to gene regulation. We focus on the intersection between metabolism and gene regulation to learn which genes to affect to engineer specific traits.

Primordial Gene Targets

Primary gene targets for major diseases have been defined, ranked, and partitioned by functional category (eg. GPCRs, receptor tyrosine kinases, transporters, ion channels, and more!).

Cellular Mechanisms

Defined cell-types matching each gene target inform target ranking, specificity, and functional effects.

Any Trait

Our proprietary methods, data lakes, data labels, and metadata enable us uncover primary gene targets for almost any disease or trait.

Discovery

Brocade AI

Functionally validated algorithms turn 100 million years of evolution uncovered biomedical superpowers into drug targets.

Brocade weaves together genomic and phenotypic data from hundreds of species with metabolic data and high-resolution human genomic and disease data to identify and rank the most important, novel, and valuable targets for any disease.

Translation

Humanizing AI

Translates bio-mechanisms between species - learning the functional DNA code for any drug response to accurately predict human gene and cell responses.

Humanizing AI translates responses and outcomes in between species to screen, predict, and understand metabolism and drug responses like never before.

Personalization

Pathfinder AI

Predicts optimal drug dosing and timing for individual patients in real time.

Introducing true precision care. Pathfinder algorithms assess patients using behavioral AI to identify and predict optimal care. This new "Algorithms as Drugs" platform is a blue ocean for creating entirely novel blockbuster therapies with intellectual property that never expires. It's real precision medicine.

We’re moving drug-science forward.
And at the same time, backing it up.

500+

proprietary data sets.

Including novel cis-element atlas >100k beyond ENCODE.

5 years

of functional validation.

Algorithms functionally validated with 5 years of wet lab work and knockout mice.

The

First

comprehensive genetic map of mammalian and human metabolic controls.

Proprietary algorithms and deep learning models for target discovery and human translation.

The

Only

atlas of evolutionary genetic and cellular pathways for disease recovery.

Primordial gene pathways and genetic circuits.

Hard science. Functionally validated.

We're the world leaders in learning from evolution and metabolism to solve human disease.

Evolution

Metabolism

Diabetes

Neurodegeneration

Obesity

Cancer

Alzheimer's

Inflammation & Immunity

For even more reasons to use Primordial, just keep working without it.

Platform

Solutions

Science

Primordial